alpha-ketoglutaric acid: meaning, definition, pronunciation and examples

Essentially, yes. 'Alpha-ketoglutaric acid' refers to the protonated acid form, while 'alpha-ketoglutarate' or 'α-ketoglutarate' refers to its deprotonated salt or anion form, which is prevalent at physiological pH. They are used interchangeably in many contexts.

It is not a significant dietary component found directly in foods. The body synthesizes it internally. Some fermented foods or supplements may contain it or its salts (e.g., calcium AKG).

It is a central metabolic hub: 1) It's a key intermediate for ATP production in the Krebs cycle. 2) It is a precursor for the synthesis of the amino acids glutamate and glutamine. 3) It is involved in nitrogen metabolism and cellular signalling pathways.

Yes, salts like calcium alpha-ketoglutarate (Ca-AKG) are marketed as dietary supplements, often for potential anti-aging, athletic performance, or health benefits. However, robust clinical evidence for many claims is still developing, and consultation with a healthcare professional is advised.

A key intermediate compound in the Krebs cycle (citric acid cycle) of cellular respiration, involved in energy production and amino acid metabolism.

Alpha-ketoglutaric acid is usually technical/scientific in register.

Alpha-ketoglutaric acid: in British English it is pronounced /ˌælfə ˌkiːtəʊɡluːˈtærɪk ˈæsɪd/, and in American English it is pronounced /ˌælfə ˌkiːtoʊɡluːˈtærɪk ˈæsɪd/. Tap the audio buttons above to hear it.