ciclosporin: meaning, definition, pronunciation and examples
C2Technical/Scientific
Quick answer
What does “ciclosporin” mean?
An immunosuppressant drug used to prevent organ rejection after transplants.
Audio
Pronunciation
Definition
Meaning and Definition
An immunosuppressant drug used to prevent organ rejection after transplants.
A cyclic polypeptide with immunosuppressive properties, derived from a fungus, used primarily in transplant medicine and treatment of autoimmune diseases.
Dialectal Variation
British vs American Usage
Differences
In British medical literature, 'ciclosporin' is the standard spelling. In American medical literature, 'cyclosporine' is overwhelmingly preferred.
Connotations
No difference in medical meaning or connotation; purely a spelling/terminological preference.
Frequency
In the UK, 'ciclosporin' is the official BAN (British Approved Name). In the US, 'cyclosporine' is the official USAN (United States Adopted Name).
Grammar
How to Use “ciclosporin” in a Sentence
The patient was given/treated with/put on ciclosporin.Ciclosporin is used to treat/prevent/manage X.The dosage/level of ciclosporin was adjusted.Vocabulary
Collocations
Examples
Examples of “ciclosporin” in a Sentence
adjective
British English
- The patient's ciclosporin levels were within the therapeutic range.
- She is on a ciclosporin-based regimen.
American English
- The patient's cyclosporine levels were monitored closely.
- He developed cyclosporine-induced nephrotoxicity.
Usage
Meaning in Context
Academic
Used in pharmacology and transplant research papers.
Everyday
Virtually never used outside medical discussions.
Technical
Core term in transplant surgery, dermatology, and rheumatology for describing immunosuppressive regimens.
Vocabulary
Synonyms of “ciclosporin”
Vocabulary
Antonyms of “ciclosporin”
Watch out
Common Mistakes When Using “ciclosporin”
- Misspelling as 'cyclosporin' when following UK official guidance, or vice-versa.
- Pronouncing it /sɪk-/ instead of /saɪk-/.
FAQ
Frequently Asked Questions
Yes, they refer to the same immunosuppressant drug. 'Ciclosporin' is the British Approved Name, while 'cyclosporine' is the United States Adopted Name.
Common side effects include kidney toxicity, high blood pressure, tremors, increased hair growth, and gum overgrowth. It requires careful monitoring of blood levels.
Yes, it is also used in the treatment of certain autoimmune diseases like severe psoriasis, atopic dermatitis, and some forms of rheumatoid arthritis.
It has a narrow therapeutic index. Levels that are too low risk organ rejection, while levels that are too high increase the risk of serious toxicity, particularly to the kidneys.
An immunosuppressant drug used to prevent organ rejection after transplants.
Ciclosporin is usually technical/scientific in register.
Ciclosporin: in British English it is pronounced /ˌsaɪkləʊˈspɔːrɪn/, and in American English it is pronounced /ˌsaɪkloʊˈspɔːriːn/ or /ˈsaɪkloʊspɔːrɪn/. Tap the audio buttons above to hear it.
Learning
Memory Aids
Mnemonic
Think 'CYCLE + SPORE + IN': A drug from a fungal spore that puts the immune system in a cycle of suppression.
Conceptual Metaphor
A GUARD that suppresses the body's own defenses to allow a foreign organ to stay.
Practice
Quiz
What is the primary clinical use of ciclosporin?