clofibrate: meaning, definition, pronunciation and examples
Extremely RareTechnical/Medical
Quick answer
What does “clofibrate” mean?
A synthetic drug used to lower lipid levels in the blood.
Audio
Pronunciation
Definition
Meaning and Definition
A synthetic drug used to lower lipid levels in the blood.
A medication prescribed to reduce triglycerides and cholesterol, particularly of the fibrate class, which acts by activating peroxisome proliferator-activated receptors (PPARs).
Dialectal Variation
British vs American Usage
Differences
There are no significant differences in usage; both dialects use the same drug name.
Connotations
None beyond its technical meaning.
Frequency
Equally rare in both UK and US contexts, limited to specialized medical literature and practice.
Grammar
How to Use “clofibrate” in a Sentence
Patient was prescribed clofibrate.Clofibrate is used to treat hyperlipidemia.Vocabulary
Collocations
Examples
Examples of “clofibrate” in a Sentence
adjective
British English
- The clofibrate regimen was discontinued.
American English
- The patient's clofibrate dosage was adjusted.
Usage
Meaning in Context
Business
Potentially mentioned in pharmaceutical business reports, but not in general business contexts.
Academic
Exclusively in medical, pharmacological, or biochemical research papers and textbooks.
Everyday
Virtually never used in everyday conversation.
Technical
The primary context is technical medical/pharmacological discussion.
Vocabulary
Synonyms of “clofibrate”
Strong
Neutral
Weak
Vocabulary
Antonyms of “clofibrate”
Watch out
Common Mistakes When Using “clofibrate”
- Mispronouncing as 'clof-i-brate' (should be 'clo-fib-rate').
- Misspelling as 'clofiborate' or 'clofibrat'.
FAQ
Frequently Asked Questions
No, it is a first-generation fibrate and has been largely superseded by newer fibrates (e.g., fenofibrate, gemfibrozil) and statins due to a less favorable side-effect profile.
It is a fibrate, a class of drugs that acts as a peroxisome proliferator-activated receptor (PPAR) agonist to lower triglycerides.
A historical example: 'In the 1970s, clofibrate was frequently prescribed for type III hyperlipoproteinemia.'
It is associated with an increased risk of gallstones and musculoskeletal side effects, which is one reason for its decline in use.
A synthetic drug used to lower lipid levels in the blood.
Clofibrate is usually technical/medical in register.
Clofibrate: in British English it is pronounced /kləʊˈfɪbreɪt/, and in American English it is pronounced /kloʊˈfɪbreɪt/. Tap the audio buttons above to hear it.
Learning
Memory Aids
Mnemonic
Think: CLOse to the FIBRin (blood-related) to help the blood stATE. It's a FIBR-ate drug.
Practice
Quiz
Clofibrate is primarily used to treat: