diastereoisomer: meaning, definition, pronunciation and examples

C2
UK/ˌdaɪ.əˌster.i.əʊˈaɪ.sə.mə/US/ˌdaɪ.əˌster.i.oʊˈaɪ.sə.mɚ/

Technical / Scientific

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Quick answer

What does “diastereoisomer” mean?

A type of stereoisomer where molecules are not mirror images of each other and are not superimposable.

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Pronunciation

Definition

Meaning and Definition

A type of stereoisomer where molecules are not mirror images of each other and are not superimposable.

In chemistry, any stereoisomer that is not an enantiomer; diastereomers have different physical properties and can be separated by conventional methods like chromatography or distillation.

Dialectal Variation

British vs American Usage

Differences

No significant difference in meaning or usage. Spelling is consistent.

Connotations

None beyond the scientific definition.

Frequency

Used with identical frequency and context in UK and US academic and industrial chemistry.

Grammar

How to Use “diastereoisomer” in a Sentence

The reaction yielded two diastereoisomers.Compound X exists as a pair of diastereoisomers.We separated the diastereoisomers by HPLC.

Vocabulary

Collocations

strong
separate diastereoisomersdiastereoisomeric excess (de)diastereoisomeric pairform a diastereoisomer
medium
pure diastereoisomermixture of diastereoisomersratio of diastereoisomers
weak
major diastereoisomersingle diastereoisomerrelative configuration

Examples

Examples of “diastereoisomer” in a Sentence

adjective

British English

  • The diastereoisomeric mixture was analysed.
  • We observed diastereoisomeric enrichment.

American English

  • The diastereomeric mixture was analyzed.
  • We observed diastereomeric enrichment.

Usage

Meaning in Context

Business

Not used.

Academic

Core term in organic and medicinal chemistry, biochemistry, and pharmacology for discussing stereoselective synthesis and drug action.

Everyday

Virtually never used.

Technical

Essential term in chemical research, patent literature, and pharmaceutical development.

Vocabulary

Synonyms of “diastereoisomer”

Weak

stereoisomer (broader term)

Vocabulary

Antonyms of “diastereoisomer”

Watch out

Common Mistakes When Using “diastereoisomer”

  • Confusing it with 'enantiomer'. Incorrectly using it to describe any type of isomer (e.g., structural isomers).

FAQ

Frequently Asked Questions

Enantiomers are non-superimposable mirror images. Diastereoisomers are stereoisomers that are not mirror images of each other.

No, diastereoisomers have different physical properties (e.g., melting point, solubility), unlike enantiomers which have identical physical properties in an achiral environment.

Yes, 'diastereomer' is a common and fully acceptable shortened form of 'diastereoisomer' in modern chemical literature.

It is crucial in organic chemistry, medicinal chemistry, pharmacology (as different diastereomers can have different biological activities), and the synthesis of complex natural products.

A type of stereoisomer where molecules are not mirror images of each other and are not superimposable.

Diastereoisomer is usually technical / scientific in register.

Diastereoisomer: in British English it is pronounced /ˌdaɪ.əˌster.i.əʊˈaɪ.sə.mə/, and in American English it is pronounced /ˌdaɪ.əˌster.i.oʊˈaɪ.sə.mɚ/. Tap the audio buttons above to hear it.

Learning

Memory Aids

Mnemonic

Think: 'DIA' as in 'different' or 'diagonal' – these isomers are DIfferent And not mirror images.

Practice

Quiz

Fill in the gap
Unlike enantiomers, can often be separated using standard column chromatography.
Multiple Choice

What is the primary defining feature of a diastereoisomer?